Inflammatory bowel disease (IBD) coincides with profound shifts in microbiota and host metabolic energy supply and demand.The gastrointestinal epithelium is anatomically positioned to provide a 2018 nissan sentra windshield selective barrier between the anaerobic luminal microbiota and host lamina propria, with the microbiota and epithelium participating in an intricate energy exchange necessary for homeostasis.Maintenance and restoration of the barrier requires high energy flux and places significant demands on available substrates to generate ATP.It is recently appreciated that components of the microbiota contribute significantly to a multitude of biochemical pathways within and outside of the mucosa.
Decades-old studies have appreciated that trophy husband apron byproducts of the microbiota provide essential sources of energy to the intestinal epithelium, especially the colon.More recent work has unveiled the existence of numerous microbial-derived metabolites that support energy procurement within the mucosa.It is now appreciated that disease-associated shifts in the microbiota, termed dysbiosis, places significant demands on energy acquisition within the mucosa.Here, we review the topic of host- and microbial-derived components that influence tissue energetics in health and during disease.